Those new performance complaints sound "non-carb" a bit, to me. If the timing changed without the distributor physically moving, that might point to an ignition electronics issue? Whereas the tip-in issues could be a combination of throttle plates being open too far at idle and accel pump being weak. For some reason, 750rpm hot base idle sounds about 50-100rpm too high to me for back then.
Personally, I like to use dwell tachs to make sure where I'm with carburetor things and such. I could never see that much difference when we started to get the first RFG and then E10, other than a 3% loss in gas mileage. My adjustments didn't change that much, if any. I gave up on vac gauges for adjustments in about 1969, when I got my first dwell tach, fwiw. NOT that a vac gauge can't be used, just that I liked the higher precision of the dwell tach for what I wanted to do. Just my experiences. Obviously others' experience with E10 has been different than mine. BTAIM Whatever works . . .
The sudden flooding issue is interesting. Normally, flaky needle and seats or fluid-filled floats are culprits. Another possibility is that the idle air bleeds for the idle system or main system suddenly became much smaller in diameter, which would send those circuits toward "full rich" just with that change. Those air bleeds are exposed to incoming air specifically, inside the throttle bore near the air cleaner base.
Check for an ignition issue, which might also lead to a timing chain issue (due to age). Please advise.
I'm now curious as to what it would take to recalibrate a Rochester 2bbl to replace the Holley 2210-family carburetors? As much as I like the Holley 2210s, though.
CBODY67