At that mileage, from experience on our 383s, at about 80K miles, #5 or #7 exhaust valve was "burnt" and needed replacing. An engine miss that did not feel like the classic fouled/dead spark plug engine miss. Carb changes would not affect it until the valve job is done to fix the issue.
When it happened on our '66 Newport 383 2bbl, it was a consistent rough idle, a bit worse on acceleration, which seemed to go away at highway speed, but going up a hill took much more throttle to maintain speed. More of a "comfort" disruption than a real operational disruption, but it was still there.
If you decided to do the diagnostics by pulling spark plug wires . . . do NOT have any body part that is near the car's metal/painted/chrome surfaces! ZAPS can happen. It can take longer but you can do the same thing by pulling a plug, restarting the engine, check for smoothness, plug the wire back in, cycle repeat. If you have a vac gauge, that can work, too, in this case. Whenever the weak cyl fires, the needle on the gauge will make a sudden and precise drop in vac level.
From my experiences,
CBODY67