Okay here we go. I did some Math for you.
Put in 68s in the primaries and 74s in the Secondaries. That reduces "100%" Fuel on Primaries and "100%" on the Secondaries. for a total of 200%. 100% sounds like all the fuel lol...but its not, its relative to the area of the Jets. so a change of 25% drops 1AFR... 200% drops 4AFR. That would mean you go from a 10.5:1 cruise to a 14.5:1 cruise. This can be a tad variable due to fuel flow and such but I really expect it to be in the high 14s.
While you are at it, look at both metering blocks and tell me the number for the Powervalve restrictor sizes.
Check the cruise AFR, I bet it will be around 14.1. You gotta remember that cruise AFR could go as lean as 16:1. It just depends on if your Motor will be happy with it. But if we get it in the 14s you should be just fine.
Do one more test if the jetting is okay and go up a slight incline, then slowly put your foot down and watch vacuum and AFR when you hit the threshold where the Powervalve opens (6.5?). What will happen as you do this, the AFR will go leaner before that valve opens, so dont be surprised! If you do this test and the engine starts to go lean and stumble and cut out and then suddenly the Powervalve opens and the AFR goes richer, then we need a valve that opens sooner! Report the AFR number
If you decide to do WOT, stop instantly if you see it go above 13:1. Tell us the number you saw and ill help address that.
BTW, you went from the 78 jets to 74s. That gave a 0.6 AFR change (from 10.5:1 to 11.1:1). The total Area of a 78 Jet is 4775,94. 25% less (or 1 AFR point) would be a 1193.99 Area decrease (so..597 reduction per Jet). The 74 Jet area is 4298.66. That is a difference of 477 per jet! See how that is not quite 25% less fuel and only made a 0.6AFR difference? Mind you this is not linear because Jets flow different but I bet that with the suggested Jet numbers you will be in the Ballpark for fine tuning. The tricky part is that you cant just go off of one Jet but gotta balance 2 jets. Actually 4. It sounds kind of stupid but maybe the Carb is actually a little on the large side for your engine?
Let us know if you notice any stumble.
EDIT:
@70bigblockdodge. The accel pump circuit would not have an effect on the cruise but rather just on initial acceleration. He could see that if it goes real lean or real rich momentarily when opening the throttle. Thats another area to fine tune but as long as there is no bogging down or backfire it should be okay!?