100 psi sounds a little on the low side to me for a rebuilt motor… the erratic vac reading sounds suspiciously like an intake valve that is leaking slightly
Honestly, if it IS a fresh rebuild, a compression reading like that is indicative of cylinder rings that haven't seated yet. It takes anywhere from 500-2000 miles for rings to fully seat, depending on ring thickness, materials, and the degree of cylinder hone. On top of THAT, that excessive ring blow-by could be responsible for the erratic vacuum signal as well.
When I rebuilt my 400 back in 2020, initially I saw 105-115 compression readings on my vacuum gauge, and this was with flat top pistons too. I called the machine shop that did the work to complain and was reassured that once the rings seated, it would go up. 4 years later with a few thousand miles, I see 130 PSI on the comp gauge. That equates to nearly 10:1.
On a side note, concerning compression gauge readings: divide the # by 14.7 & add 1 to get your static compression ratio. Atmospheric pressure is 14.7 at sea level, yet the gauge reads zero. At 2:1 compression ratio, the gauge would only read 14.7 (or 15 to the naked eye if using a analog needle gauge). 100/14.7 yields 6.8, so then you add 1 and get 7.8, almost 8:1 ratio. If this was a smog era motor rebuilt to factory specs it would be perfect for a new rebuilt engine.
Dr. Dave's recommendation: drive it, take 2 tankfuls of non-ethanol gasoline and baby it, but still occasionally blast it full throttle for no more than 10 seconds each day when fully warmed up (or 2 full throttle runs at 5 seconds each depending on road & traffic conditions). This will help seat the rings. Then change the oil & retest the compression with a gauge and see if it doesn't improve.
On a fresh motor, I like to jet the carb a little rich to make sure it doesn't overheat.
And if you are using synthetic motor oil, break-in mileage is double the length of time/miles versus conventional oil. A magnetic oil plug and/or a bar magnet strapped to the oil filter isn't a bad idea either.