Ok... I'm up and this has been bothering me. Please don't take offense to this, but... the information hasn't been adding up in quite the logical way I would have hoped for. It is true that nobody has seen it all or knows it all and we all get good and stumped from time to time. But some of this information that we are answering to may be flawed.
First off... the test drive symptoms: while driving in various engine load conditions pay close attention to the feel of the engine...does it seem low on power?(many causes) Is the pulse feeling always there, or at least when somewhat under load(sign of one or more cylinders weak)? Do you feel it while sitting still and does it clear when shifted to neutral or reverse(good chance for motor mounts)? Does hot or cold engine have a great affect(many causes)? Power brake the engine not quite to the point of spinning tires for a few seconds(pronounced miss would likely be ignition)
Second... provided the cause was thought to be engine condition, like compression, vacuum gauge testing has lots of guides all over the internet. But to understand it better, just think of it as a quick way to check on your engine's ability to "breathe" properly. One cylinder not making power should show a wiggle on the gauge WHILE the engine is pulsating... more cylinders more wiggles. There is a rhythm to your engine when running that matches engine speed... the wiggles will match that rhythm and can be used to tell one vs several cylinders as suspected cause... a lower compression engine is a lower vacuum engine, but lots of factors affect this like cam profiles. Rumpty cams, make poor vacuum at idle because they don't "breathe" well at idle...they are optimized for higher RPMs.
Third, if I felt convinced the problem could be compression related, I would use a shop vac to clean any debris from around the spark plug holes and maybe degrease the area on a grimy motor. Then make sure you have a charged battery(critical) and hopefully can run a charger during the test, remove ALL spark plugs, keep them in order and photograph them so the folks here can help diagnose. Use a compression gauge that screws into the spark plug hole, cheap rubber cone ones are great for lawn mowers, and make sure the holes are clean before installing the gauge, or debris could skew results. wide open throttle, ignition coil disabled, crank about 8-10 revolutions judged by ear but should be enough that you cant go wrong. Record all readings, if the reading seem low do a wet test by dropping a teaspoon of oil or less into the spark plug holes and retest...record the readings. To interpret readings they should be within 10% of each other and close to factory specs... or without specs 90 psi ish for low compression and up to 200 psi ish for high compression... lower with rumpty cam (poor breathing at cranking speed)...its more about similar readings than specs. The wet test will usually raise compression by 5-10 psi... if more its a good indicator the rings are not sealing well. Young Mr. Horvaths has recently posted what appears to be an old sitting engine with poor results... his tests look valid and I understand "freshening up" but if it were started and run, it might just straighten itself out (compression wise) by reseating and oiling dry rings.
Fourth, if the compression results indicate a problem on any cylinder, a leakdown test would be called for. The cylinder is charged with air using a specific tool that can indicate how much air is lost. The cylinder would be positioned at TDC compression to do this so valves are closed. there WILL be leakage at the rings, so don't be fooled. Listening at the exhaust and intake can indicate valves leaking, big cracked heads,block etc can bubble through cooling system, but a lack of bubbles doesn't prove its good. If too much air leaks down...30% ish or more and only comes from crankcase (oil cap) rings are further proven. Passing leakdown results tell that its not combustion chamber related and could be cam,pushrod,valvetrain related. This is why compression results alone are usually not used to determine teardown.
If you think the head gasket or block is damaged there are combustion gas leak detection kits available cheap at your part store they are used to detect CO2 gases at the radiator fill point and used a blue fluid that turns yellow in CO2 concentrations... you and your engine produce CO2. CAUTION do not let the fluid get contaminated or it wont work.
This, my friends, is not the most comprehensive diagnostic available, but covers much of the ground in this thread. A professional will NEVER disable an engine until the cause has been pinpointed because if he doesn't find it at teardown, it will like return after repairs. I am not an engine builder, but have built a few and repaired many, you wont see or measure a problem you haven't diagnosed beforehand too often for a engine pro to fall into that trap.
Feel free to make corrections or point out omissions... or hell just argue... but maybe this will help