Unlike the similar Edelbrock/Carter carbs, the restrictions in the Holley carbs are in the metering block. NOT accessible from "the outside" of it, but through drilled passages. What you are spraying on top, in the venturi, are the "air bleed" correction/fine tuning calibration items. THOSE bleeds go rich when they get deposits on them to decrease their size.
Get some fuel cleaning additive with the "PEA" additive in it to clean things up. Gumout is one brand that has that additive in it. It also cleans the combustion chambers, too.
As to a rebuild, that can be done . . . but my experiences with my 4175 is that sometime in the 1990s, Holley changed their metering block/plate gaskets, plus the bowl gaskets, such that they look like they have some sort of shellac coating on them. With ALSO glues the two parts they are between, together! It might be difficult to get the float bowls off, but impossible (without breaking something!) to get the metering block off of the main body. I did get the rear metering plate off, plus the metal plate it seals against, but had to sand the paper gasket OFF of the metal plate. I ended up getting another carb! Just be advised.
I'd recommend the fuel cleaner first. No real need for "spirited driving", to me, unless that's what you desire to do. IF you want max cleaning, you might do some shorter trips instead, to allow the cleaner to soak the suspected deposits, between times. "Spirited driving" can help any carbon deposits in the combustion chambers, I suspect.
I concur on spraying a good carb cleaner into the idle mixture holes (with the screws removed). Look at the pcv passages, too. Brake cleaner might work, but not as well as carb cleaner will.
Just my experiences,
CBODY67