Really have to see what it looks like under the spare. Also look at the floor extensions. These are the vertical pieces that connect to the edge of the trunk floor and the lower edge of the quarter panel.
Based on what I see, there's a few options.
Best, as been said, is replacing the entire floor. No doubt about it. It's a serious project though and I don't know your capabilities or what you have available for tools.
Second best, and
this is all dependent of the condition of the rest of the floor, is to replace those just parts that are rusted though with patches. Some sheet metal and a cheap MIG welder can take care of the job pretty fast.
Down the list a little farther is something like I did with a spare tire wheel on a '53 Chrysler. This HAS TO BE NON STRUCTURAL. Nothing near a frame etc. but this beats the aluminum flashing/pop rivet repair that I've seen in a lot of cars hands down. It's strong and will last.
View attachment 327573
Cut a piece of fiberglass cloth to cover it.
View attachment 327574
Painted the area with POR-15 paint and put the 'glass cloth on top and soaked it with POR-15
View attachment 327575
Did a couple more layers and it was good and solid.
Again, that is a repair for a section that
doesn't involve the structure of the car. Some will disagree, but whatever... It will take a couple hours and you can focus on something else.