I installed one in my A12 Roadrunner years ago.
The issue was that I would have to move the car around in the driveway/garage often without taking it for a drive. It was jetted a little fat and that didn't help. I wouldn't say the plugs fouled, but they would get a little dark and the car was hard to start. I went to the MSD and those problems never happened again. I gapped the plugs to .055" and ran it with the stock dual point. When I sold the car, the next owner put in a Mopar Perf distributor and ECU and he asked me about the MSD. He came back to me saying how much better it ran with the MSD.
The cool thing about using the dual point with the MSD, the points never burnt. I replaced them when I put the MSD in and drove that car thousands of miles and never had to change the points. I think I adjusted the gap once over that time. With the MSD, the points don't carry the amount of current that the conventional ignition does.
Mileage? Who knows? I was happy to get double digits. Drivability? Yep, much better starting.
Also used an MSD-7 with the car I dragged 40 years ago. We stopped needing to run warm up plugs once I started using the MSD.
Put an MSD on my AMC Jeep Wagoneer when the Ford based ignition crapped out. Again, great starting, although I never noted any improvement in mileage.
I have an MSD sitting on my shelf that was given to me. I was told it had an intermittent problem, but I suspect it was something else, like wiring or coil. I've been thinking about using with my 300L and again, using the dual point to trigger it.